This section explores the Impact Initiative’s approach to identifying research projects that combine to provide coherent messages for decision makers. Specifically, it looks at a series of outputs called Research for Policy and Practice (R4PP) papers that have enabled grantholders to respond to live policy issues. It sets out what the Impact Initiative was trying to achieve and the advantages of this approach over both lengthier systematic reviews and summaries of single studies. It answers the question: How did this meso-synthesis of evidence, combined with policy events, manage to promote diverse perspectives and provide compelling narratives for decision makers? We believe this approach could be adapted for other programme-level knowledge-brokering functions that seek to maximise the impact of research.